Increasingly climate-related disasters in the Amazon impact millions, but underreporting and lack of standardized data hinder effective response efforts. Transboundary cooperation is essential to address shared challenges and implement evidence-based policies. To enhance disaster response and preparedness, we recommend: 1) standardizing disaster reporting practices among Amazon countries; 2) including global support for regional disaster mitigation in CoP30 commitments; 3) developing a transboundary preparedness strategy; 4) strengthening and connecting cross-border early- warning systems; and 5) reinforcing local and regional policies for climate change adaptation. These actions are crucial to break the cycle of damage and safeguard lives, livelihoods, and nature.