The Dávalos Lab conducts research on extinction and survival in deep time, genetics and genomics of non-model vertebrates, and deforestation.
William Thomas won the Society for Systematic Biologists' [Graduate Student Research Award] (https://www.systbio.org/graduate-student-research-awards.html)! The award will help William generate population genetic/epigenetic data for discovering shrew wintering adaptations!
Kristjan Mets won the Presidential Dissertation Completion Fellowship! The award will help Kristjan to complete his dissertation over the summer!
Anna McPherran won the Williams award at the 2021 Ecology & Evolution retreat. The award will help Anna sequence the genomes of hutias!
Liliana M. Dávalos is Professor of Conservation Biology at Stony Brook University’s Department of Ecology and Evolution. Her research interests include molecular evolution, phylogenetics, and tropical conservation.
PhD in Ecology, Evolution,and Environmental Biology, 2004
Columbia University (New York, New York)
Certificate in Environmental Policy Studies, 2001
Columbia University (New York, New York)
BSc in Biology (emphasis on Genetics), 1997
Universidad del Valle (Cali, Colombia)
Taught evolution and researched molecular ecology
To investigate evolution and mechanisms of seasonal reversible size changes in a mammal.See notice
For outstanding teaching and true caring for students.
Symposia bring together outstanding young scientists to discuss exciting advances and opportunities in a broad range of disciplines.See profile
Data available to new students. Why are bats so likely to carry coronaviruses, yet seem little affected by them? Many studies have focused on their immune system, but there is much to learn about the cells viruses attack upon entry.
Data available to new students. All aspects of society have been upended by COVID-19. While most research has understandably focused on clinical applications, how the ancestors of SARS-CoV2 survive and circulate in nature is vital to both prevent future epidemics and help health professionals develop therapeutic treatments.
In support of RA Kristjan Mets. While scientific reaction to the COVID-19 pandemic has been swift, the risk of SARS-CoV-2 spilling back into native North American wildlife and feral domestic animals remains underexplored. Experimental infections of a variety of hosts, serological analyses of the cats in Wuhan, and cases of COVID-19 among tigers and lions in the Bronx Zoo, all have shown transmission back to wildlife and feral cats is highly probable. Tools are urgently needed to determine which of these animal populations are at greatest risk of establishing a native reservoir, and where the overlap with human populations is greatest. We propose to model the risk of spillover to animal populations and conversely the risk of future secondary spillover by combining models of molecular interaction between the virus and potential hosts, with multi- species Susceptible-Infectious-Recovered (SIR) models. Complementing decades of experience in vertebrate genomics (Dávalos) with expertise in epidemiology (Meliker), and spatial dynamics of wildlife disease (Mets), ours is the ideal team to quickly generate and test the necessary models to avert this risk.
To answer the question of how the shrew shrinks and then regrows its brain, we will establish this unusual species as a new model, by studying the biological, molecular, biochemical and genetic processes behind this reversible size change.
Data available for new students. We assembled a group of socio-environmental scientists to analyze and model the natural and human factors that determine the extinction and resilience of insular vertebrate fauna and leverage this understanding into metrics for use in conservation assessments.
We propose to develop a cross-scale research program that focuses on the relationships between phylogenetic diversity, genetic diversity and functional diversity of a biologically and economically important taxonomic group; bats.
Data available to new students. This project focuses on pairs of closely related bat species that sharply differ in their longevity. Detailed genome comparisons between closely related species with different life spans will test different theories of aging.
This training program responds to the challenges of new careers at the interface between science and decision making with an interdisciplinary set of new courses and a suite of activities united by the theme of “Scientific Training and Research to Inform DEcisions” (STRIDE).
Data available to new students. The project focuses on a relatively unexplored yet crucial aspect of plant-animal mutualisms; volatile chemical communication between plants and vertebrate frugivores.
Data available to new students. This project focuses on a diverse group of tropical bats in which various species evolved acute, specialized hearing, supersensitive eyes, the ability to smell subtle plant chemicals, or highly developed vomeronasal systems (thought to contribute to mating and social hierarchy).
The goal of this project was to discover the mechanisms underlying the survival of remnant populations in the WNS-affected area.
Noctilionoid bats comprise more than 200 species that span the entire ecological diversity of land mammals. They range from tiny insectivores and nectarivores to large carnivores, and even vampire bats. This is an unparalleled system for understanding how, when, and where bats evolved new diets, changed roosting habits and developed different kinds of echolocation. Together with the N. B. Simmons Lab, we are generating species-level phylogenies using molecular and morphological data, and including fossils of >20 extinct species. These phylogenies provide frameworks for investigating patterns and processes of ecological adaptation, speciation, and extinction across a hyperdiverse group of mammals.
The project will generate hypotheses about the evolutionary relationships of 5 different groups of bats, each containing at least one exclusively Antillean species. These evolutionary relationships will then be used to establish the timing and pattern of separation among bat species in the Antilles and their South and Central American relatives, and will also be compared with similar hypotheses about other terrestrial organisms. Drs. Nancy Simmons, Rob DeSalle, and Liliana Davalos will use standard methods for obtaining and analyzing morphological and molecular data from the study groups. Patterns of evolutionary relationships resulting from these data will be compared applying at least 5 different approaches.
Comprising more than 1,400 species, bats possess adaptations unique among mammals including powered flight, unexpected longevity, and extraordinary immunity. Some of the molecular mechanisms underlying these unique adaptations includes DNA repair, metabolism and immunity. However, analyses have been limited to a few divergent lineages, reducing the scope of inferences on gene family evolution across the Order Chiroptera. We conducted an exhaustive comparative genomic study of 37 bat species, one generated in this study, encompassing a large number of lineages, with a particular emphasis on multi-gene family evolution across immune and metabolic genes. In agreement with previous analyses, we found lineage-specific expansions of the APOBEC3 and MHC-I gene families, and loss of the proinflammatory PYHIN gene family. We inferred more than 1,000 gene losses unique to bats, including genes involved in the regulation of inflammasome pathways such as epithelial defense receptors, the natural killer gene complex and the interferon-gamma induced pathway. Gene set enrichment analyses revealed genes lost in bats are involved in defense response against pathogen-associated molecular patterns and damage-associated molecular patterns. Gene family evolution and selection analyses indicate bats have evolved fundamental functional differences compared to other mammals in both innate and adaptive immune system, with the potential to enhance anti-viral immune response while dampening inflammatory signaling. In addition, metabolic genes have experienced repeated expansions related to convergent shifts to plant-based diets. Our analyses support the hypothesis that, in tandem with flight, ancestral bats had evolved a unique set of immune adaptations whose functional implications remain to be explored.
The role of mechanical morphologies in the exploitation of novel niche space is well characterized, however, the role of sensory structures in unlocking new niches is less clear. Here we investigate the relationship between the evolution of sensory structures and diet during the radiation of noctilionoid bats. With a broad range of foraging ecologies and a well- supported phylogeny, noctilionoids constitute an ideal group for studying this relationship. We used diffusible iodine-based contrast enhanced computed tomography (diceCT) scans of 44 noctilionoid species to analyze relationships between the relative volumes of three sensory structures (olfactory bulbs, orbits, and cochleae) and diet. We found a positive relationship between frugivory and both olfactory and orbit size. However, we also found a negative relationship between nectarivory and cochlea size. Ancestral state estimates suggest that larger orbits and olfactory bulbs were present in the common ancestor of family Phyllostomidae, but not in other noctilionoid. This constellation of traits indicates a shift toward omnivory at the base of Phyllostomidae, predating their radiation into an exceptionally broad range of dietary niches. This is consistent with a scenario in which changes in sensory systems associated with foraging and feeding set the stage for subsequent morphological modification and diversification.